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pentobarbital will decrease the level or result of tamoxifen by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Observe.pentobarbital will decrease the extent or impact of naloxegol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Utilization of naloxegol with powerful CYP3A4 inducers just isn't recommendedpen